Klinefelter syndrome can often be managed through regular checkups, medications, and counseling. Other treatments for Klinefelter syndrome include: speech and language therapy physical therapy to improve muscle strength occupational therapy to help you function day to … What Is Klinefelter Syndrome? J Clin EndocrinolFeaturesMetab. Some treatments for the symptoms of Klinefelter syndrome can include: Hormone replacement. Normally the cells in men's bodies have a single X chromosome along with a Y chromosome, while women's cells have two X chromosomes. Treatment can help males overcome many of the physical, social, and learning problems associated with the syndrome. The therapy is initiated at the time of puberty to enable the body to change normally as it should. About Klinefelter Syndrome Klinefelter Syndrome (KS) is a condition that occurs in men who have one or more extra X chromosomes. Treatment of Klinefelter Syndrome Klinefelter Syndrome is a genetic mutation, and hence it has no cure but certain pharmacological therapies can … Klinefelter syndrome (KS) is a genetic condition in which boys are born with an extra copy of the X chromosome (piece of genetic material). Klinefelter syndrome treatment. Klinefelter syndrome is quite common, affec… Materials and methods: A total of 91 microdissection testicular sperm extraction attempts were done in 68 men with nonmosaic Klinefelter's syndrome. The primary features are infertility and small poorly functioning testicles. Males with Klinefelter syndrome should be seen by a team of health care providers. However, most men can expect to live a long, full life. Males with Klinefelter syndrome should be seen by a team of health care providers. Klinefelter syndrome is caused by an additional X chromosome in males (47,XXY). Our doctors work with patients’ primary care providers to identify specialty needs, to coordinate care, and to improve outc… Intellig The team may include endocrinologists, general practitioners, pediatricians, urologists, speech therapists, genetic counselors, and psychologists. Treatment with androgens reduces gynecomastia and evidence of male hypogonadism and increases strength and libido in patients with all variants of Klinefelter syndrome. Early intervention can prevent some symptoms from occurring. But this type of treatment is not suitable because surgery causes greater pain and also costs higher. Klinefelter syndrome is a genetic condition that occurs when a boy is born with an extra copy of the X chromosome. Klinefelter syndrome is a fairly common genetic condition found in males only.. KS is also called 47, XXY. Klinefelter syndrome, also known as 47,XXY is the set of symptoms that result from two or more X chromosomes in males. Since there are low levels of testoterone in Klinefelter syndrome, the number one treatment suggested is testosterone replacement therapy to prevent the severe lifelong effects of the disorder. The following list of medications are in some way related to, or used in the treatment of this condition. Klinefelter syndrome is an uncommon genetic disorder, and it can only be diagnosed after laboratory tests are completed to determine if an individual has the disorder. Appointments & Access. Often it is only at puberty that these symptoms are noticed. Treatment Options for Klinefelter Syndrome . Management of Klinefelter Syndrome: The management of Klinefelter syndrome in the Allopathy medicine system is done with Psychological counseling, Fertility treatment, Breast tissue removal, and Testosterone replacement therapy. Clinical Features of Klinefelter Syndrome Groth K et al. Klinefelter syndrome occurs if boys are born with an extra X chromosome. In 1942, Klinefelter et al published a report describing nine men with a constellation of features: testicular dysgenesis, microorchidism, eunuchoidism, gynecomastia, elevated urinary gonadotropins, and azoospermia. OTC. This results in stunted puberty, smaller than average genitals, and the development of breasts and infertility. Klinefelter syndrome is a genetic condition that affects males physical, behavioral, and cognitive development and functioning. Drugs used to treat Klinefelter Syndrome. The treatment for Klinefelter syndrome is aimed in addressing the major manifestations of the disease. While Klinefelter syndrome cannot be cured, some of its symptoms can be improved by testosterone replacement therapy, which restores testosterone levels to normal range. Klinefelter syndrome can shorten a male’s life expectancy up to two years. This shall replace what the patient is lacking and require at the time of puberty. [] The etiology was thought to be due to an endocrine disorder of unknown cause, until 1959, when Jacobs et al recognized that Klinefelter syndrome was a … Men with Klinefelter syndrome can now have children, if they want, with new forms of in-vitro fertilisation. If treatment is needed, it’s recommended that they begin as early as possible, preferably during puberty or childhood. Men with serum testosterone less than 300 ng/dl received medical therapy with aromatase inhibitors, clomiphene or human chorionic gonadotropin before microdissection testicular sperm extraction. Sometimes, symptoms are more evident and may include weaker muscles, greater height, poor coordination, less body hair, breast growth, and less interest in sex. Klinefelter syndrome is a sex chromosome disorder in boys and men that results from the presence of an extra X chromosome in cells. Testosterone replacement therapy: Since males with Klinefelter syndrome don't produce enough testosterone, undergoing testosterone replacement therapy at the onset of puberty can allow a … Treatment is usually in the form of an injection, pills, gel, or a patch. People with Klinefelter syndrome can experience breast growth, breast cancer, osteoporosis, infertility and learning difficulties. It was clinically described for the first time by Kleinfelter in 1942. If you or your son is diagnosed with Klinefelter syndrome, your health care team may include a doctor who specializes in diagnosing and treating disorders involving the body's glands and hormones (endocrinologist), a speech therapist, a pediatrician, a physical therapist, a genetic counselor, a reproductive medicine or infertility specialist, and a counselor or psychologist. https://patient.info/mens-health/klinefelters-syndrome-leaflet This page of the eMedTV library discusses these options along with other possible treatments for Klinefelter syndrome, with links to additional information. The following are the proposed remedies of the syndrome: Androgen therapy. Females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY). Many boys with Klinefelter syndrome — also known as XXY syndrome — have no signs or symptoms, and some don't even know they have it until later in life.. People typically have 46 chromosomes in each cell, two of which are the sex chromosomes. The MassGeneral Hospital for Children Klinefelter Syndrome clinic takes a multidisciplinary approach to providing quality, coordinated care to individuals living with Klinefelter syndrome. Surgery may be needed to reduce breast size. Surgery. Klinefelter syndrome. 2013 (98): 20 –30 Frequency (%) Infertility (adults) Small testes Azoospermia (adults) 91-99 >95 >95 Learning disabilities (children) Often, symptoms are subtle and subjects do not realize they are affected. However, most men can expect to live a long, full life. Klinefelter syndrome treatment with homeopathy is also prominent for treating secondary symptoms. Treatment of Klinefelter syndrome may include: Genetic counseling to discuss long-term complications Special education programs (including speech therapy, occupational therapy, or other therapies) Klinefelter disease is characterized by the presence of at least one extra X chromosome in boys, which leads to impaired puberty in them. Testosterone replacement therapy improves, strength, body hair growth, … Treatments Treatment with testosterone and/or a medicine to prevent excess estrogen production may be given to help normalize secondary sexual development and improve libido, strength, mood and thinking. In some cases, surgery may be necessary to correct certain symptoms of Klinefelter syndrome, such as abnormal breast tissue. Clinical findings are nonspecific during childhood; thus, the diagnosis commonly is … The population frequency is 1: 1000 males. 47, XXY is the most common of the X and Y variants and approximately, 1 in 500 males has an extra copy of the X chromosome. This is a significant treatment for the affected. Treatment involves the targeted administration of male hormones (androgens), such as testosterone enanthate, cypionate, or androgel. This treatment should begin at puberty or as soon after as possible. Therapy. Mild cases of Klinefelter syndrome may require no treatment. A person with KS has 47 chromosomes inside their cells instead of the usual 46. Testosterone therapy can help with many of the symptoms of Klinefelter syndrome. With treatment, men can lead very normal lives. Although there's no way to repair the sex chromosome changes due to Klinefelter syndrome, treatments can help minimize its effe… Select drug class All drug classes androgens and anabolic steroids (1) Rx. Klinefelter syndrome is a chromosomal disorder that occurs when a male is born with an additional X chromosome. Klinefelter syndrome, 47, XXY is a clinical example of sex chromosome lesions. Treatment typically involves physical and emotional therapy, as well as hormone replacement. Klinefelter syndrome is a genetic disorder caused by the acquirement of an extra X chromosome in males (XXY instead of XY). What is the treatment for Klinefelter syndrome? Treatment One of the hallmarks of Klinefelter syndrome is hypergonadotropic hypogonadism, a condition that results in testosterone deficiency. Boys and men with Klinefelter syndrome are still genetically male and often will not realize they have this extra X chromosome (47, XXY), but occasionally it can cause problems that may require treatment, problems such as a small penis, small testes and infertility. Klinefelter syndrome can be diagnosed through genetic testing, semen analysis and blood tests to measure hormones. The syndrome can affect boys and men at different stages of life and their physical, language, and social development. 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